Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Veklich, T. O.
Pathways and mechanisms of transmembrane calcium ions exchange in the cell nucleus / T. O. Veklich, Yu. V. Nikonishyna, S. O. Kosterin // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P5-24

MeSH-головна:
КЛЕТКИ ЯДРО -- CELL NUCLEUS (метаболизм)
КАЛЬЦИЙ -- CALCIUM (метаболизм)
НУКЛЕОПЛАЗМИНЫ -- NUCLEOPLASMINS (метаболизм)
Анотація: A variety of nuclear calcium functions includes regulations of gene transcription and permeability of nuclear pore complexes, activation of numerous enzymes involved in the apoptosis, and therefore cell fate determination. Thus, the pathways of Ca2+ entry into the nucleus, the interplay between nuclear and cytosolic calcium signals, calcium accumulation in the nuclear depot, extrusion and subsequent destinies are of particular interest. In this review, we systematized literature data and our results about aspects of calcium transport in the cell. We especially concentrated on calcium transport systems and general mechanisms of calcium exchange in the central organelle – the nucleus. We also described the general structure of the cell nucleus, nuclear envelope transporters, and the role of Ca2+ in the nucleus and disturbances of nuclear calcium signaling
Дод.точки доступу:
Nikonishyna, Yu. V.
Kosterin, S. O.

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The P60-S6K1 isoform of ribosomal protein S6 kinaze 1 is a product of alternative mRNA translation / I. V. Zaiets [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P25-35

MeSH-головна:
РИБОСОМНЫЕ ПРОТЕИН-S6 КИНАЗЫ -- RIBOSOMAL PROTEIN S6 KINASES (метаболизм)
РНК ИЗОФОРМЫ -- RNA ISOFORMS (метаболизм)
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION
Анотація: Ribosomal protein S6 kinase 1 (S6K1) is a well-known downstream effector of mTORC1 (mechanistic target of rapamycin complex 1) participating primarily in the regulation of cell growth and metabolism. Deregulation of mTOR/S6K1 signaling can promote numerous human pathologies, including cancer, neurodegeneration, cardiovascular disease, and metabolic disorders. As existing data suggest, the S6K1 gene encodes several protein isoforms, including p85-S6K1, p70-S6K1, and p60-S6K1. The two of these isoforms, p85-S6K1 and p70-S6K1, were extensively studied to date. The origin and functional significance of the p60-S6K1 isoform remains a mystery, however, it was suggested that the isoform could be a product of alternative S6K1 mRNA translation. Herein we report the generation of HEK-293 cells exclusively expressing p60-S6K1 as a result of CRISPR/Cas9-mediated inactivation of p85/p70-S6K1 translation. Moreover, the generated modified cells displayed the elevated level of p60-S6K1 expression compared to that in wild-type HEK-293 cells. Our data confirm an assumption that p60-S6K1 is alternatively translated, most probably, from the common for both p70- and p85-S6K1 mRNA transcript and reveal a link between p60-S6K1 expression and such cellular processes as cell proliferation and motility. In addition, our findings indicate that the p60-S6K1 isoform of S6K1 may undergo a mode of regulation distinct from p70- and p85-S6K1 due to the absence of mTOR-regulated p60-S6K1 phosphorylation at T389 that is important for S6K1 activation
Дод.точки доступу:
Zaiets, I. V.
Sivchenko, A. S.
Khoruzhenko, A. I.
Savinska, L. O.
Filonenko, V. V.

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Liver cytochrome P450-hydroxylation system of tumor-bearing rats under the influence of ?-3 polyunsaturated fatty acids and vitamin D3 / I. O. Shymanskyi [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P36-44

MeSH-головна:
ПЕЧЕНИ НОВООБРАЗОВАНИЯ ЭКСПЕРИМЕНТАЛЬНЫЕ -- LIVER NEOPLASMS, EXPERIMENTAL (лекарственная терапия, метаболизм)
ЖИРНЫЕ КИСЛОТЫ НЕНАСЫЩЕННЫЕ -- FATTY ACIDS, UNSATURATED
ВИТАМИН D -- VITAMIN D
ЦИТОХРОМРЕДУКТАЗЫ -- CYTOCHROME REDUCTASES (действие лекарственных препаратов)
ЦИТОХРОМОВ P-450 ФЕРМЕНТНАЯ СИСТЕМА -- CYTOCHROME P-450 ENZYME SYSTEM (действие лекарственных препаратов)
Анотація: The study was performed to investigate the effects of the separate and combined action of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and vitamin D3 on the activity of the components of the oxygenase and reductase chains of the monooxygenase system (MOS) in the microsomal fraction isolated from the liver of rats with transplanted Guerin carcinoma. In the liver of the tumor-bearing rats during the intensive growth of the tumor (14 days, which corresponds to the logarithmic phase of tumor growth), the functional activity of the MOS was weakened. N-demethylase, p-hydroxylase and NADPH-cytochrome P450 reductase activity decreased, with the simultaneous enhancement of cytochrome P450 inactivation rate due to its transformation into an inactive form, cytochrome P420. In turn, we found an increase in the functional activity of the reductase chain of MOS, which components are known to transfer electrons from the reduced NADH through NADH-cytochrome b5-reductase and cytochrome b5 to cytochrome P450. In particular, the activity of NADH-cytochrome b5-reductase and the rate of reduction of cytochrome b5 were elevated with a simultaneous decrease in its content. Both ω-3 PUFAs and vitamin D3 administration to tumor-bearing rats for 42 days (28 days of preliminary administration and 14 days of tumor growth) significantly normalized the oxygenase activity of MOS, increasing NADPH-cytochrome P450-reductase, N-demethylase and p-hydroxylase activity of cytochrome P450 and blocking cytochrome P450 inactivation rate in the microsomal fraction of the liver. Administration of ω-3 PUFAs in combination with vitamin D3 led to the synergy. Changes in the activity of the components of the reductase chain of MOS in liver of tumor-bearing rats were observed mainly after ω-3 PUFAs supplementation. The content of cytochrome b5 increased and the rate of its reduction was significantly diminished. In the absence of a pronounced individual effect of vitamin D3 on the reductase chain of MOS, its co-administration with ω-3 PUFA was also found to be ineffective
Дод.точки доступу:
Shymanskyi, I. O.
Ketsa, O. V.
Marchenko, M. M.
Veliky, M. M.

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Ajilore, B. S.
Gentamicin and magnesium chloride normalizes cholinesterase and ATPase activities in rats acutely exposed to dichlorvos (DDVP) pesticide / B. S. Ajilore, A. E. Adewuyi, T. O. Oluwadairo // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P45-51

MeSH-головна:
ПЕСТИЦИДЫ -- PESTICIDES (отравления, токсичность)
ХИМИЧЕСКИ-ИНДУЦИРОВАННЫЕ РАССТРОЙСТВА -- CHEMICALLY-INDUCED DISORDERS (лекарственная терапия, этиология)
ГЕНТАМИЦИНЫ -- GENTAMICINS
АТРОПИН -- ATROPINE
МАГНИЯ ХЛОРИД -- MAGNESIUM CHLORIDE
ЭКСПЕРИМЕНТЫ НА ЖИВОТНЫХ -- ANIMAL EXPERIMENTATION
Анотація: This study investigated possible use of gentamicin and magnesium chloride as antidotes of dichlorvos pesticide poisoning. Thirty albino rats were randomly divided into 5 groups (n = 6). Group 1 served as negative control and received distilled water only. Group 2 served as positive control and was treated with 2.5 mg/kg body weight dichlorvos intraperitoneally. Group 3 was post-treated with 0.5 mg atropine following intraperitoneal 2.5 mg/kg dichlorvos while groups 4 and 5 rat were post-treated with 28 mg/kg intramuscular magnesium chloride and 5 mg/kg intramuscular gentamicin respectively following intraperitoneal 2.5 mg/kg dichlorvos. Plasma and red blood cell acetylcholinesterase activities were estimated. Total ATPase, Na+/K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase activities were estimated in the brain. Results showed significant (P 0.05) increase in acetylcholinesterase activities in rats post treated with Atropine, MgCl2 and Gentamicin when compared with acetylcholinesterase activities in rats treated with dichlorvos only. There is significant (P 0.05) increase in the activities of Ca2+,Mg2+-ATPases, Na+/K+-ATPase and total ATPase activities in the brain of rats post treated with atropine, magnesium chloride and gentamicin. Dichlorvos significantly (P 0.05) reduced plasma and red blood cell cholinesterase activities, and brain ATPases activities. We concluded that dichlorvos toxicity inhibited cholinesterase, Na+/K+-ATPase and Ca2+,Mg2+-ATPases activities. Magnesium chloride and gentamicin on the other hand reduced effects of dichlorvos poisoning by promoting normal ATPase activities and inhibiting release of acetylcholine from cell. We proposed that both magnesium chloride and gentamicin can be co-administered in future as antidotes to patients with dichlorvos poisoning
Дод.точки доступу:
Adewuyi, A. E.
Oluwadairo, T. O.

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Adenosine thiamine triphosphate and adenosine thiamine triphosphate hydrolase activity in animal tissues / A. F. Makarchikov [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P52-63

MeSH-головна:
АДЕНОЗИНТРИФОСФАТ -- ADENOSINE TRIPHOSPHATE (метаболизм)
АДЕНОЗИНДЕЗАМИНАЗА -- ADENOSINE DEAMINASE (метаболизм)
ТКАНИ -- TISSUES (метаболизм)
ЭУКАРИОТЫ -- EUKARYOTA
Анотація: Adenosine thiamine triphosphate (AThTP), a vitamin B1 containing nucleotide with unknown biochemical role, was found previously to be present in various biological objects including bacteria, yeast, some human, rat and mouse tissues, as well as plant roots. In this study we quantify AThTP in mouse, rat, bovine and chicks. We also show that in animal tissues the hydrolysis of AThTP is catalyzed by a membrane-bound enzyme seemingly of microsomal origin as established for rat liver, which exhibits an alkaline pH optimum of 8.0-8.5 and requires no Mg2+ ions for activity. In liver homogenates, AThTP hydrolase obeys Michaelis-Menten kinetics with apparent Km values of 84.4 ± 9.4 and 54.6 ± 13.1 µМ as estimated from the Hanes plots for rat and chicken enzymes, respectively. The hydrolysis of AThTP has been found to occur in all samples examined from rat, chicken and bovine tissues, with liver and kidney being the most abundant in enzyme activity. In rat liver, the activity of AThTP hydrolase depends on the age of animals
Дод.точки доступу:
Makarchikov, A. F.
Saroka, T. V.
Kudyrka, T. G.
Kolas, I. K.
Luchko, T. A.
Rusina, I. M.
Gurinovich, V. A.

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Kaplia, A. A.
Assessment of the effect of monohydroxy alcohols, unsaturated fatty acids, organophosphate compounds on the enzymatic ATP-hydrolysis in the cell membranes of the smooth muscle of the rat colon / A. A. Kaplia, S. V. Midyk, S. V. Khyzhnyak // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P64-73

MeSH-головна:
МЫШЦА ГЛАДКАЯ -- MUSCLE, SMOOTH (действие лекарственных препаратов, метаболизм)
ОБОДОЧНАЯ КИШКА -- COLON (действие лекарственных препаратов, метаболизм)
СПИРТЫ -- ALCOHOLS
ЖИРНЫЕ КИСЛОТЫ НЕНАСЫЩЕННЫЕ -- FATTY ACIDS, UNSATURATED
ФОСФОРОРГАНИЧЕСКИЕ СОЕДИНЕНИЯ -- ORGANOPHOSPHORUS COMPOUNDS
КРЫСЫ -- RATS
Анотація: The differences of the structural-functional stability of ATP-hydrolases to the action of the short-chain aliphatic monohydroxy alcohols and long-chain unsaturated fatty acids (UFAs) with wide range of the membrane-acting effectiveness were evaluated in the colonic smooth muscle (CSM) cellular membranes. It was shown that Mg2+,ATP-hydrolase was more resistant to all tested aliphatic compounds than Na+,K+-ATPase. There was a clear relationship between inhibitory efficiency, chain length (number of carbons) increase and relative polarity decrease in the series of straight-chain alcohols. Secondary alcohol 2-propanol turned out to be the weaker inhibitor than primary alcohol 1-propanol. The I50 value (мМ) for ATРases decreased in the following succession: ethanol 2-propanol 1-propanol 1-butanol. UFAs were the stronger inhibitors (I50 of μM range) than alcohols (mM range). Oleic acid inhibited Na+,K+-ATPase with lower efficiency than was detected for arachidonic acid according to the differences in double bonds number; I50 for Mg2+,ATP-hydrolase activity was the same for studied UFAs. As well, the organophosphate pesticide fenamiphos proved to be a weak ATPase inhibitor. Comparison of the enzymatic pair of the CSM ATP-hydrolases seems applicable for evaluation of the specific membrane-acting effect of bioactive compounds on Na+,K+-ATРase activity from the standpoint of its role in mediating of electro-mechanical coupling in intestinal smooth muscles
Дод.точки доступу:
Midyk, S. V.
Khyzhnyak, S. V.

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Yukalo, V. G.
Isolation of к-CN-1P and β-CN-5P fractions from native casein micelles / V. G. Yukalo, L. A. Storozh // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P74-79

MeSH-головна:
КАЗЕИНЫ -- CASEINS (метаболизм)
ПЕПТИДЫ -- PEPTIDES (метаболизм)
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ -- CHROMATOGRAPHY, LIQUID (использование, методы)
ЭЛЕКТРОФОРЕЗ -- ELECTROPHORESIS (использование, методы)
Анотація: Proteins of the casein complex of milk arouse considerable interest as the precursors of biologically active peptides which are capable of influencing various physiological systems of the body (digestive, nervous, cardiovascular, and immune). It has been established that various bioactive peptides are unevenly located in the structure of casein fractions. In this connection, there appeared a need to separate individual fractions of this protein for studying the pathways of formation and properties of bioactive casein peptides. To minimize negative effects of the purification procedure, we used the gel filtration on Sefarose 2B to produce native casein micelles and repeating filtration on Sephadex G-150 to separate individual fractions. As a result, according to electrophoretic analysis, casein micelles with a characteristic protein composition were obtained. Taking into account the similarity of the molecular weight of components for their dividing the repeated gel filtration was carried out with separating the chromatograms into sectors. The composition of the combined fractions of each sector was analyzed by electrophoresis. This approach allowed isolating two electrophoretically homogeneous proteins from native casein micelles – κ-CN-1P and β-CN-5P, as well as to obtain a substantially purified ( 83%) αS1-CN-XP. Isolated caseins without the influence of extreme factors can be used to study natural bioactive peptides
Дод.точки доступу:
Storozh, L. A.

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Bobrovnik, S. A.
Effect of trifluoroethanol on antibody reactivity against corresponding and nonrealated antigens / S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P80-89

MeSH-головна:
ТРИФТОРЭТАНОЛ -- TRIFLUOROETHANOL
ИММУНОГЛОБУЛИНЫ -- IMMUNOGLOBULINS (действие лекарственных препаратов, метаболизм)
АНТИГЕН-АНТИТЕЛО РЕАКЦИИ -- ANTIGEN-ANTIBODY REACTIONS (действие лекарственных препаратов)
Анотація: The ability of antibodies to switch between specific and nonspecific recognition of antigens under various factors is the key issue. Here we demonstrate that 2,2,2-trifluoroethanol (TFE) is one of these factors influencing the ability of monoclonal antibodies to react specifically with corresponding antigen (ovalbumin) and transforming them into polyreactive immunoglobulins (PRIGs) that are strong but nonspecific binders with various antigens. Such switching of antibody reactivity is nonlinear and even nonmonotonous function of TFE concentration and depends strongly on incubation time and temperature. At room temperatures (25 °C) the specific antibodies under 30% TFE action are transformed into PRIGs. However, at 0 °C the variation of antibody reactivity is complicated. TFE is known as the alcohol with one of the strongest proton-donor abilities in hydrogen bonding and its effect is probably in binding to specific sites that switch the antibody recognition ability
Дод.точки доступу:
Demchenko, M. O.
Komisarenko, S. V.

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Nitrate and nitrite in drinking water affect antioxidant enzymes in erythrocytes of rats / E. Sierra-Campos [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P90-101

MeSH-головна:
НИТРАТЫ -- NITRATES
НИТРИТЫ -- NITRITES
ПИТЬЕВАЯ ВОДА -- DRINKING WATER
ОКСИДАТИВНЫЙ СТРЕСС -- OXIDATIVE STRESS (действие лекарственных препаратов)
МЕТГЕМОГЛОБИН -- METHEMOGLOBIN (действие лекарственных препаратов, метаболизм)
ЭРИТРОЦИТЫ -- ERYTHROCYTES (действие лекарственных препаратов, метаболизм)
КРЫСЫ -- RATS
Анотація: The present study evaluated the effect of short term intake of nitrite and nitrate drinking water on the antioxidant system and membrane damage of rat erythrocytes. Wistar rats were randomly divided into three groups as follows; the group I received only distilled water ad libitum; the group II was given water with nitrate (a dose of 124 mg/kg of nitrate-nitrogen) as drinking water and the group III was given nitrites dissolved in distilled water in a dose of 150 mg/kg for 7 days. At the end of the study, group III rats showed a significant decrease in activities of glutathione peroxidase (GPx), glucose 6-phosphate dehydrogenase (G6PDH) and catalase (CAT), while in group II rats, the activity of GPx and CAT were significantly reduced, but no significant changes in glutathione reductase activity and peroxynitrite levels were observed. On the other hand, malondialdehyde (MDA) was increased in both groups with respect to group I. Also, our major results indicate that all treatments changed methemoglobin levels and osmotic fragility in comparison to group I rats. The intensity of alterations was found more severe in rats of group III, followed by rats of group II. It can be concluded from these observations that nitrate or nitrite leads to alterations in the erythrocytes antioxidant defense status mainly throughout NADPH relate enzymes
Дод.точки доступу:
Sierra-Campos, E.
Valdez-Solana, M. A.
Campos-Almazan, M. I.
Avitia-Dominguez, C.
Hernandez-Rivera, J. L.
de Lira-Sanchez, J. A.
Garcia-Arenas, G.
Tellez-Valencia, A.

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10.

Salyha, N. O.
Effects of L-glutamic acid and pyridoxine on glutathione depletion and lipid peroxidation generated by epinephrine-induced stress in rats / N. O. Salyha // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P102-110

MeSH-головна:
ГЛУТАМИНОВАЯ КИСЛОТА -- GLUTAMIC ACID
ПИРИДОКСИН -- PYRIDOXINE
АДРЕНАЛИН -- EPINEPHRINE
ОКСИДАТИВНЫЙ СТРЕСС -- OXIDATIVE STRESS (действие лекарственных препаратов)
ГЛУТАТИОН -- GLUTATHIONE (действие лекарственных препаратов, метаболизм)
КРЫСЫ -- RATS
Анотація: The main goal of this research was to investigate and compare the protective effects of L-glutamic acid (L-Glu) alone and combined with Pyridoxine (L-Glu+Pyridoxine) for the purpose of suppression and mitigation of epinephrine-induced stress in rats. This study outlines possible links between changes of reduced glutathione (GSH) level, antioxidant enzymes activity and content of the lipid peroxidation products after administration of the above-mentioned substances and under the action of stress in various tissues of rats. The obtained results suggest that the GSH level was significantly inhibited by stress in all investigated tissues (except kidneys). We have shown that under the stress, activities of glutathione-associated enzymes were changed (mainly decreased) in all investigated tissues. In rats, additionally received L-Glu and L-Glu+Pyridoxine, much less changes or lack of changes in studied parameters were observed. The content of lipid peroxidation products (lipid peroxides (LOOH) and thiobarbituric acid reactive substances (TBARS)) in myocardium, liver and kidney tissues of experimental groups under the stress conditions were significantly higher compared to the control. While in experimental groups that received L-Glu and L-Glu+Pyridoxine LOOH content in kidney, spleen and liver and TBARS content in spleen, liver and myocardium were almost at the level of control values. These results indicate that L-Glu and L-Glu+Pyridoxine can mitigate and suppress epinephrine-induced stress in rats
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11.

Evaluation of serum adenosine deainase and its isoenzymes in patients with ovarian cancer / A. Asadi [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P111-114

MeSH-головна:
ЯИЧНИКОВ НОВООБРАЗОВАНИЯ -- OVARIAN NEOPLASMS (метаболизм, этиология)
АДЕНОЗИНДЕЗАМИНАЗА -- ADENOSINE DEAMINASE
МИОЗИНЫ -- MYOSINS
Анотація: Ovarian cancer is the most lethal gynecological cancer worldwide. There are great relationships between the activities of adenosine deaminase (ADA), one of the enzymes in purine nucleotide pathway and carcinogenic process. In the present study the activities of the total ADA, ADA1 and ADA2 were measured in the sera of the patients with ovarian cancer. In this study, activities of tADA, ADA1 and ADA2 were assessed in sera of 30 patients with ovarian cancer and 30 normal control individuals, using a modified Ellis method in which only ADA2 activity was measured in the present of a specific inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA). Our results showed that the tADA, ADA1, and ADA2 serum activities of patients were found to be significantly increased (P 0.05) than those of healthy control group. Although, ADA and its isoenzymes were not the specific markers for diagnosis of ovarian cancer, measurement of their activities may be used as a diagnostic means in ovarian cancer as well as the other analytical procedures
Дод.точки доступу:
Asadi, A.
Atyabi, S. M.
Sadeghi, S.
Khatami, S.
Ebrahimi-Rad, M.
Valadbeigi, S.
Saghiri, R.

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12.

Ozbolat, Guluzar.
Hematologic features of beta-globin gene mutation type (??) with homozygous beta thalassemia / Guluzar Ozbolat, Abdullah Tuli // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P115-120

MeSH-головна:
БЕТА-ТАЛАССЕМИЯ -- BETA-THALASSEMIA (генетика, диагностика, этиология)
СЕКВЕНИРОВАНИЕ ДНК -- SEQUENCE ANALYSIS, DNA (использование, методы)
ГЕНЕТИЧЕСКАЯ ИЗМЕНЧИВОСТЬ -- GENETIC VARIATION
Анотація: β-Tthalassemia is common genetic disorders in Turkey that characterized by the reduced synthesis (β+) or absence (βo) of the β-globin chains in the HbA molecule. In this study, we aimed to determine the effect of the mutation type of the β-globin gene on hematological values in homozygous β-thalassemia. This retrospective study was undertaken by Prenatal Diagnosis Centres of Cukurova University Medical Biochemistry at Adana. We evaluated 60 homozygous by implementing DNA sequencing analysis for mutations undetectable by conventional methods. 30 patients with βo [FSC 44/ C-A] mutations and the other 30 patients with βo [(IVS-II-1(GA), CD39 (CT), Cd8 (-AA) Cd39 C T and CD36/37 (–T)] mutations, totally 60 patients were included in the study. Erythrocyte indices, HbF, HbA2 levels were compared between the two groups. FSC 44/(-C) mutations were detected in patients. Hb, Hct, MCV in this group values were statistically lower than in patients with other detected mutations (P 0.05). Between the two groups, there is no statistically different RBC, MCH, MCHC, HbF, HbA2 levels (P ˃ 0.05). For the first time in this study, it was found that the Hb, Hct and MCV value of the persons who carried the FSC 44/(-C) mutation were significantly lower than the persons who carrying other mutations. Between the two groups, there was no statistical difference in RBC, MCH, MCHC, HbF and HbA2 levels. Awareness of FSC/44 mutation, which may have a heterogeneous clinical presentation, is required. We herein present the hematologic findings of a Turkish population carrying this mutation. This will also help to make a diagnosis
Дод.точки доступу:
Tuli, Abdullah

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13.

Данилова, В. М.
Альфред Бернгард Нобель і Нобелівська премія / В. М. Данилова, Р. П. Виноградова, С. В. Комісаренко // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P121-134

MeSH-головна:
НОБЕЛЕВСКАЯ ПРЕМИЯ -- NOBEL PRIZE
ИСТОРИЯ 19 ВЕКА -- HISTORY, 19TH CENTURY
Анотація: The great number of pages has been written about Alfred Nobel and his Prize in various languages all over the world, but in this article we elucidated only two issues: what kind of person was Alfred Nobel – this phenomenon in experimental chemistry, doctor of philosophy, academician, who had no higher education, the founder of the fund for rewarding with the prize named after him, and what kind of award is the Nobel Prize, how is it awarded and how this Prize influences the trend of science marked with this award. The answer to the question why Nobel Prizes are unique and most prestigious ones may be as follows: they were introduced timely, and they define fundamental historical changes in society. The Nobel Committee activities actually direct scientists, writers and public figures to work throughout the year for the sake of society development, for the sake of progress common to all mankind
Дод.точки доступу:
Виноградова, Р. П.
Комісаренко, С. В.
Нобель, Альфред Бернард (хімік, інженер, винахідник ; 1833-1896) \про нього\

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14.

Danylova, T. V.
Scientific investigation of Nobel prize winner Emil Fischer as a launching pad for the development of biochemistry: a brief overview / T. V. Danylova, S. V. Komisarenko // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 4. - P135-142

MeSH-головна:
БИОХИМИЯ -- BIOCHEMISTRY (история, кадры)
НОБЕЛЕВСКАЯ ПРЕМИЯ -- NOBEL PRIZE
Анотація: Modern biochemistry and molecular biology would be impossible without discoveries in related fields of science. This paper aims to outline briefly the main stages of scientific activity of a Nobel Prize winner 1902 – German chemist Hermann Emil Fischer, one of the leading chemists of all times. Emil Fischer was a brilliant multifaceted scientist who left his mark in organic chemistry, physiology, medicine, gave impetus to the development of biochemistry. His insights into the structures of sugars, enzymes, proteins, and purines have become a launching pad for the further development of biochemistry and molecular biology. His contribution to the natural sciences was immense; some chemical reactions and concepts were named after him. This prominent scientist was honored with a number of awards
Дод.точки доступу:
Komisarenko, S. V.

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© Міжнародна Асоціація користувачів і розробників електронних бібліотек і нових інформаційних технологій
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